General Information

  • ID:  hor003513
  • Uniprot ID:  P37086
  • Protein name:  Orcokinin
  • Gene name:  NA
  • Organism:  Faxonius limosus (Spinycheek crayfish) (Orconectes limosus)
  • Family:  Orcokinin family
  • Source:  animal
  • Expression:  Abdominal nerve cord and hindgut.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Faxonius (genus), Cambarinae (subfamily), Cambaridae (family), Astacoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NFDEIDRSGFGFN
  • Length:  13
  • Propeptide:  NFDEIDRSGFGFN
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic peptide, enhances both the frequency and amplitude of spontaneous hindgut contractions.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003513_AF2.pdbhor003513_ESM.pdb

Physical Information

Mass: 173179 Formula: C67H92N18O23
Absent amino acids: ACHKLMPQTVWY Common amino acids: F
pI: 3.88 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -82.31 Boman Index: -4011
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 30
Instability Index: 4997.69 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1480511
  • Title:  Orcokinin: A Novel Myotropic Peptide From the Nervous System of the Crayfish, Orconectes Limosus